Bacterial RNase P: a new view of an ancient enzyme

  title={Bacterial RNase P: a new view of an ancient enzyme},
  author={Alexei V. Kazantsev and Norman R. Pace},
  journal={Nature Reviews Microbiology},
Ribonuclease P (RNase P) is a ubiquitous endonuclease that catalyses the maturation of the 5′ end of transfer RNA (tRNA). Although it carries out a biochemically simple reaction, RNase P is a complex ribonucleoprotein particle composed of a single large RNA and at least one protein component. In bacteria and some archaea, the RNA component of RNase P can catalyse tRNA maturation in vitro in the absence of proteins. The discovery of the catalytic activity of the bacterial RNase P RNA triggered… CONTINUE READING