Bacterial RNA thermometers: molecular zippers and switches

@article{Kortmann2012BacterialRT,
  title={Bacterial RNA thermometers: molecular zippers and switches},
  author={Jens Kortmann and Franz Narberhaus},
  journal={Nature Reviews Microbiology},
  year={2012},
  volume={10},
  pages={255-265}
}
Bacteria use complex strategies to coordinate temperature-dependent gene expression. Many genes encoding heat shock proteins and virulence factors are regulated by temperature-sensing RNA sequences, known as RNA thermometers (RNATs), in their mRNAs. For these genes, the 5′ untranslated region of the mRNA folds into a structure that blocks ribosome access at low temperatures. Increasing the temperature gradually shifts the equilibrium between the closed and open conformations towards the open… 

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