Bacterial RNA polymerase inhibitors: an organized overview of their structure, derivatives, biological activity and current clinical development status.

Abstract

RNA polymerase (RNAP) currently represents an important target for the development of new antibacterial agents. RNAP is a nucleotidyl transferase enzyme able to generate an RNA copy of a DNA or RNA template chain, controlling initiation and termination of transcription. RNAP is found in nature in all eukaryotes, prokaryotes and archaea, as well as in many… (More)

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