Bacterial NAD(P)-independent quinate dehydrogenase is a quinoprotein

  title={Bacterial NAD(P)-independent quinate dehydrogenase is a quinoprotein},
  author={Mario A. G. van Kleef and Johannis A. Duine},
  journal={Archives of Microbiology},
Acinetobacter calcoaceticus LMD 79.41 produced significant amounts of pyrrolo-quinoline quinone (PQQ) in its culture medium when grown on quinic acid or shikimic acid. Studies with LMD 79.41 and PQQ--mutants of this strain demonstrated that this organism contains an NAD(P)-independent quinate dehydrogenase (QDH) (EC 1.1.99.-), catalyzing the first degradation step of these compounds, and that the enzyme contains PQQ as a cofactor, i.e. is a quinoprotein. Synthesis of QDH was induced by… CONTINUE READING