Bacterial Epigenomics: Coming of Age

@article{Oliveira2021BacterialEC,
  title={Bacterial Epigenomics: Coming of Age},
  author={Pedro H. Oliveira},
  journal={mSystems},
  year={2021},
  volume={6}
}
Epigenetic DNA methylation in bacteria has been traditionally studied in the context of antiparasitic defense and as part of the innate immune discrimination between self and nonself DNA. However, sequencing advances that allow genome-wide analysis of DNA methylation at the single-base resolution are nowadays expanding and have propelled a modern epigenomic revolution in our understanding of the extent, evolution, and physiological significance of methylation. ABSTRACT Epigenetic DNA… 
2 Citations

Growth Condition Dependent Differences in Methylation Implies Transiently Differentiated DNA Methylation States in E. coli

TLDR
Oxford Nanopore sequencing is used to profile DNA modification marks in three natural isolates of E. coli to provide new insights into the dynamics of methylation during bacterial growth, and provide evidence of differentiated cell states, a transient analogue to what is observed in the differentiation of cell types in multicellular organisms.

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