Bacterial DNA repair genes and their eukaryotic homologues: 1. Mutations in genes involved in base excision repair (BER) and DNA-end processors and their implication in mutagenesis and human disease.

@article{Krwawicz2007BacterialDR,
  title={Bacterial DNA repair genes and their eukaryotic homologues: 1. Mutations in genes involved in base excision repair (BER) and DNA-end processors and their implication in mutagenesis and human disease.},
  author={Joanna Krwawicz and Katarzyna D. Arczewska and Elżbieta Speina and Agnieszka Maciejewska and Elzbieta Grzesiuk},
  journal={Acta biochimica Polonica},
  year={2007},
  volume={54 3},
  pages={413-34}
}
Base excision repair (BER) pathway executed by a complex network of proteins is the major system responsible for the removal of damaged DNA bases and repair of DNA single strand breaks (SSBs) generated by environmental agents, such as certain cancer therapies, or arising spontaneously during cellular metabolism. Both modified DNA bases and SSBs with ends other than 3'-OH and 5'-P are repaired either by replacement of a single or of more nucleotides in the processes called short-patch BER (SP… CONTINUE READING

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