Bacterial DNA or oligonucleotides containing unmethylated CpG motifs can minimize lipopolysaccharide-induced inflammation in the lower respiratory tract through an IL-12-dependent pathway.

@article{Schwartz1999BacterialDO,
  title={Bacterial DNA or oligonucleotides containing unmethylated CpG motifs can minimize lipopolysaccharide-induced inflammation in the lower respiratory tract through an IL-12-dependent pathway.},
  author={David A Schwartz and Christine L. Wohlford-Lenane and Thomas J Quinn and Arthur M. Krieg},
  journal={Journal of immunology},
  year={1999},
  volume={163 1},
  pages={224-31}
}
To determine whether the systemic immune activation by CpG DNA could alter airway inflammation, we pretreated mice with either i.v. bacterial DNA (bDNA) or oligonucleotides with or without CpG motifs, exposed these mice to LPS by inhalation, and measured the inflammatory response systemically and in the lung immediately following LPS inhalation. Compared with non-CpG oligonucleotides, i. v. treatment with CpG oligonucleotides resulted in higher systemic concentrations of polymorphonuclear… CONTINUE READING

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Interferon- in the Management of Infectious Diseases

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