Bacterial Biofilms on the Sinus Mucosa of Human Subjects With Chronic Rhinosinusitis

  title={Bacterial Biofilms on the Sinus Mucosa of Human Subjects With Chronic Rhinosinusitis},
  author={Alicia R. Sanderson and Jeff G. Leid and Darrell H. Hunsaker},
  journal={The Laryngoscope},
Introduction: Chronic rhinosinusitis (CRS) is a common disease poorly controlled by antibiotics. Postulated etiologies of CRS include allergy, fungi, functional factors, and biofilm. 
Are biofilms associated with an inflammatory response in chronic rhinosinusitis?
The objective of this study was to further evaluate the role of biofilms in CRS by assessing whether they are associated with an inflammatory response.
Bacterial biofilms in patients with chronic rhinosinusitis
The possible presence of biofilms was examined in mucosal specimens of 15 patients, undergoing functional endoscopic sinus surgery or a modified Caldwell-Luc approach for chronic rhinosinusitis
Microbiology of Chronic Frontal Rhinosinusitis
The role of microbiology in chronic frontal rhinosinusitis remains poorly understood and the value of antimicrobial therapy is unclear in chronic forms of frontal rhinocerosinusitis.
Staphylococcus aureus biofilms
This work aimed to prospectively investigate the effects of Staphylococcus aureus, Pseudomonas aeruginosa, Haemophilus influenzae, and fungal biofilms on outcomes following endoscopic sinus surgery (ESS).
Manuka honey sinus irrigation for the treatment of chronic rhinosinusitis: a randomized controlled trial
Manuka honey (MH) has been shown in vitro to be effective against biofilm‐producing bacteria. This study assessed the effectiveness of MH for patients with active chronic rhinosinusitis (CRS) and
Implications of bacterial biofilms in chronic rhinosinusitis.
The main characteristics of biofilm are reviewed, the current methods used to demonstrate biofilms in chronic rhinosinusitis are described and the future directions of research in the field are discussed.
Are biofilms the answer in the pathophysiology and treatment of chronic rhinosinusitis?
Paired analysis of the microbiota of surface mucus and whole‐tissue specimens in patients with chronic rhinosinusitis
The role of bacteria in the pathogenesis of chronic rhinosinusitis (CRS) remains uncertain and there has been no systematic comparison of bacterial community composition and diversity in the surface mucosa with that of the underlying tissue.
Role of Bacterial and Fungal Biofilms in Chronic Rhinosinusitis
Research will ultimately solidify the nature and extent of the contribution of biofilms in CRS pathogenesis and focus on evidence-based antibiofilm treatments with reference to efficacy and timing of treatment.


Bacterial Biofilms in Surgical Specimens of Patients with Chronic Rhinosinusitis
It is hypothesize that biofilms play a role in chronic rhinosinusitis (CRS) and the goal is to demonstrateBiofilms in mucosal specimens of patients undergoing surgery for CRS.
Evidence of Bacterial Biofilms in Human Chronic Sinusitis
Morphologic structures that confirm the presence of bacterial biofilms were identified on the sinus mucosa of patients infected with Pseudomonas aeruginosa, a known biofilm former, which may explain the recalcitrant nature of some forms of chronic sinusitis.
Chronic rhinosinusitis and biofilms
Adult Chronic Rhinosinusitis: Definitions, Diagnosis, Epidemiology, and Pathophysiology
  • M. Benninger, B. Ferguson, H. Levine
  • Medicine
    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • 2003
Bacteriology of chronic purulent secretions in chronic rhinosinusitis.
The amoxycillin-clavulanate combination was the most active oral antibiotic tested against the pathogenic species in vitro.
Bacteriologic findings associated with chronic bacterial maxillary sinusitis in adults.
  • S. Finegold, M. J. Flynn, B. Wynne
  • Medicine, Biology
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2002
Recurrences of signs or symptoms of bacterial maxillary sinusitis associated with anaerobes were twice as frequent as were those associated with aerobes when counts of anaerOBes were > or =10(3) cfu/mL.
Bacterial biofilms: an emerging link to disease pathogenesis.
This chapter discusses three infections that are caused by biofilms--infectious kidney stones, bacterial endocarditis, and cystic fibrosis lung infections--and focuses on the role of the biofilm in disease pathogenesis.
Candidate's Thesis: Direct Evidence of Bacterial Biofilms in Otitis Media
  • J. Post
  • Medicine
    The Laryngoscope
  • 2001
Visual evidence is collected of the formation of bacterial biofilms on middle‐ear mucosa of chinchillas in an experimental model of OME and in children with refractory post‐tympanostomy otorrhea.
The application of biofilm science to the study and control of chronic bacterial infections.
The potential benefits of the application of the new methods and concepts developed by biofilm science and engineering to the clinical management of infectious diseases are discussed.
The Microbiology of Chronic Rhinosinusitis: Results of a Community Surveillance Study
It is suggested that culture- and sensitivity-directed therapy should be effective in the treatment of chronic rhinosinusitis and the prevalence of beta-lactamase-positive H influenzae was consistent with other reports, and a lower prevalence of polymicrobial flora was found.