Bacterial Biofilms in Surgical Specimens of Patients with Chronic Rhinosinusitis

  title={Bacterial Biofilms in Surgical Specimens of Patients with Chronic Rhinosinusitis},
  author={Jose A. Sanclement and P. M. Webster and John G. Thomas and Hassan Ramadan},
  journal={The Laryngoscope},
Objectives: Biofilms are bacterial pathogens that organize in several chronic and recalcitrant infectious processes. We hypothesize that biofilms play a role in chronic rhinosinusitis (CRS). Our goal is to demonstrate biofilms in mucosal specimens of patients undergoing surgery for CRS. 
Bacterial biofilms in patients with chronic rhinosinusitis
The possible presence of biofilms was examined in mucosal specimens of 15 patients, undergoing functional endoscopic sinus surgery or a modified Caldwell-Luc approach for chronic rhinosinusitis
Are biofilms associated with an inflammatory response in chronic rhinosinusitis?
The objective of this study was to further evaluate the role of biofilms in CRS by assessing whether they are associated with an inflammatory response.
Bacterial Biofilms on the Sinus Mucosa of Human Subjects With Chronic Rhinosinusitis
Chronic rhinosinusitis is a common disease poorly controlled by antibiotics and postulated etiologies include allergy, fungi, functional factors, and biofilm.
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The main characteristics of biofilm are reviewed, the current methods used to demonstrate biofilms in chronic rhinosinusitis are described and the future directions of research in the field are discussed.
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Whether different biofilm species have different disease outcomes is investigated in Chronic Rhinosinusitis patients.
Are biofilms the answer in the pathophysiology and treatment of chronic rhinosinusitis?
Role of Bacterial and Fungal Biofilms in Chronic Rhinosinusitis
Research will ultimately solidify the nature and extent of the contribution of biofilms in CRS pathogenesis and focus on evidence-based antibiofilm treatments with reference to efficacy and timing of treatment.
Biofilms in Chronic Rhinosinusitis: A Review
Bacterial biofilms appear to contribute to the progression of chronic rhinosinusitis in a subset of patients, although substantial effort toward therapeutic intervention is still necessary.
Biofilms and nasal wound healing in postsurgical patients with chronic rhinosinusitis - A review of literature
This review aims to highlight the relationship between bacterial biofilm and CRS, and also the available treatment strategies of the latter.
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A literature review focuses on biofilms and exotoxins that act as superantigens that play an important pathological role in the incidence, maintenance, and ongoing burden of chronic rhinosinusitis.


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Evidence that otitis media with effusion may represent a chronic infective state such as those evidenced in conditions secondary to biofilms or small colony variants is discussed and why this may be important in the future management of this condition is explained.
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Improvements in understanding of the genetic and molecular basis of bacterial community behavior point to therapeutic targets that may provide a means for the control of biofilm infections.
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The sticky conglomerations of bacteria known as biofilms are being linked to common human diseases ranging from tooth decay to prostatitis and kidney infections, and a new program at the National Institutes of Health is working to understand how and why they form.
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