Bacterial Biofilms in Surgical Specimens of Patients with Chronic Rhinosinusitis

@article{Sanclement2005BacterialBI,
  title={Bacterial Biofilms in Surgical Specimens of Patients with Chronic Rhinosinusitis},
  author={Jose A. Sanclement and P. M. Webster and John G. Thomas and Hassan Ramadan},
  journal={The Laryngoscope},
  year={2005},
  volume={115}
}
Objectives: Biofilms are bacterial pathogens that organize in several chronic and recalcitrant infectious processes. We hypothesize that biofilms play a role in chronic rhinosinusitis (CRS). Our goal is to demonstrate biofilms in mucosal specimens of patients undergoing surgery for CRS. 
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References

SHOWING 1-10 OF 26 REFERENCES
Is otitis media with effusion a biofilm infection?
TLDR
Evidence that otitis media with effusion may represent a chronic infective state such as those evidenced in conditions secondary to biofilms or small colony variants is discussed and why this may be important in the future management of this condition is explained.
Chronic rhinosinusitis and biofilms
Bacterial biofilms: a common cause of persistent infections.
TLDR
Improvements in understanding of the genetic and molecular basis of bacterial community behavior point to therapeutic targets that may provide a means for the control of biofilm infections.
Forging a Link Between Biofilms and Disease
TLDR
The sticky conglomerations of bacteria known as biofilms are being linked to common human diseases ranging from tooth decay to prostatitis and kidney infections, and a new program at the National Institutes of Health is working to understand how and why they form.
Candidate's Thesis: Direct Evidence of Bacterial Biofilms in Otitis Media
  • J. Post
  • Medicine
    The Laryngoscope
  • 2001
TLDR
Visual evidence is collected of the formation of bacterial biofilms on middle‐ear mucosa of chinchillas in an experimental model of OME and in children with refractory post‐tympanostomy otorrhea.
Bacterial resistance to antibiotics: the role of biofilms.
  • B. Hoyle, J. Costerton
  • Medicine, Biology
    Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques
  • 1991
Bacteria adhere to natural and synthetic, medically important surfaces within an extracellular polymer generically termed the glycocalyx. This quasi-structure is a biofilm. The enhanced antibiotic
Adult Chronic Rhinosinusitis: Definitions, Diagnosis, Epidemiology, and Pathophysiology
  • M. Benninger, B. Ferguson, H. Levine
  • Medicine
    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • 2003
Ultrastructural preservation of biofilms formed by non-typeable Hemophilus influenzae
TLDR
Although high-pressure freezing of NTHi biofilms followed by freeze substitution was highly effective for preserving ultrastructure when examined by transmission electron microscopy, immersion in liquid propane offered an alternative, “less technical”, freezing method.
Chemoprophylaxis of Fungal Deterioration of the Provox Silicone Tracheoesophageal Prosthesis in Postlaryngectomy Patients
TLDR
The use of a buccal bioadhesive slow-release tablet containing an antimycotic agent proves to be an adequate method of preventing fungal colonization and deterioration of silicone voice prostheses.
Biofilms: Microbial Life on Surfaces
  • R. Donlan
  • Biology
    Emerging infectious diseases
  • 2002
TLDR
A greater understanding of biofilm processes should lead to novel, effective control strategies for biofilm control and a resulting improvement in patient management.
...
...