Bacteria differentially induce degradation of Bcl-xL, a survival protein, by human platelets.

@article{Kraemer2012BacteriaDI,
  title={Bacteria differentially induce degradation of Bcl-xL, a survival protein, by human platelets.},
  author={Bjoern F. Kraemer and Robert Hugh Campbell and Hansj{\"o}rg Schwertz and Zechariah Gideon Franks and Adriana Vieira de Abreu and Katharina Grundler and Benjamin T Kile and Bijaya Kumar Dhakal and Matthew T Rondina and Walter H A Kahr and Matthew A. Mulvey and Robert C. Blaylock and Guy A Zimmerman and Andrew S. Weyrich},
  journal={Blood},
  year={2012},
  volume={120 25},
  pages={
          5014-20
        }
}
Bacteria can enter the bloodstream in response to infectious insults. Bacteremia elicits several immune and clinical complications, including thrombocytopenia. A primary cause of thrombocytopenia is shortened survival of platelets. We demonstrate that pathogenic bacteria induce apoptotic events in platelets that include calpain-mediated degradation of Bcl-x(L), an essential regulator of platelet survival. Specifically, bloodstream bacterial isolates from patients with sepsis induce lateral… CONTINUE READING
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