Bacteremia due to Acinetobacter baumannii: epidemiology, clinical findings, and prognostic features.

Abstract

The number of nosocomial infections caused by Acinetobacter baumannii has increased in recent years. During a 12-month study, there were 1.8 episodes of A. Baumannii bacteremia per 1,000 adults admitted to a hospital in Seville, Spain. Seventy-nine patients were included in the study. A. baumannii bacteremia occurred after a mean (+/- SD) hospitalization of 18 +/- 20 days. In all cases the infections were acquired nosocomially; 71% wee acquired in intensive care units. Ampicillin/ sulbactam was found to be the most active agent against A. baumannii. The common source of the bacteremia was the respiratory tract (32 cases [71%]). Twenty patients (25%) had septic shock, and 24 (30%) had disseminated intravascular coagulation (DIC). Treatment with imipenem or ampicillin/sulbactam was most effective (cure rates, 87.5% and 83%, respectively). The deaths of 27 patients (34%) were related to A baumannii bacteremia. The presence of DIC (odds ratio [OR] = 116.4; P < .0001) and inappropriate antimicrobial treatment (OR = 15.2; P < .01) were independently associated with mortality. We conclude that most A. baumannii isolates are multiresistant and that nosocomial A. baumannii bacteremia may cause severe clinical disease that is associated with a high mortality.

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@article{Cisneros1996BacteremiaDT, title={Bacteremia due to Acinetobacter baumannii: epidemiology, clinical findings, and prognostic features.}, author={Jose Cisneros and Manuel Reyes and Jer{\'o}nimo Pach{\'o}n and Berta Becerril and Francisco Javier Caballero and Jos{\'e} Luis Garc{\'i}a-Garmendia and Carolyne Ortiz and A R Cobacho}, journal={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America}, year={1996}, volume={22 6}, pages={1026-32} }