Baclofen suppresses motivation to consume alcohol in rats

@article{Colombo2003BaclofenSM,
  title={Baclofen suppresses motivation to consume alcohol in rats},
  author={Giancarlo Colombo and Giovanni Vacca and Salvatore Serra and Giuliana Brunetti and Mauro A. M. Carai and Gian Luigi Gessa},
  journal={Psychopharmacology},
  year={2003},
  volume={167},
  pages={221-224}
}
RationaleRecent studies demonstrated that treatment with the γ-aminobutyric acid (GABA)B receptor agonist baclofen reduced alcohol intake in selectively bred Sardinian alcohol-preferring (sP) rats tested under the home-cage, two-bottle choice regimen.ObjectivesThe present study investigated the effect of baclofen on the appetitive, rather than consummatory, aspects of alcohol ingestion in sP rats.MethodsRats were trained to lever-press for oral alcohol (10%, v/v) or sucrose (3%, w/v) under a… CONTINUE READING
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References

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SHOWING 1-10 OF 12 REFERENCES

Behavioral neurobiology of alcohol addiction: recent advances and challenges.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 2002
VIEW 1 EXCERPT

GABAB receptor agonists for the treatment of drug addiction: a review of recent findings

MS Cousins, DCS Roberts, H de Wit
  • Drug Alcohol Depend
  • 2002
VIEW 2 EXCERPTS