Baclofen reverses the reduction in prepulse inhibition of the acoustic startle response induced by dizocilpine, but not by apomorphine

@article{Bortolato2004BaclofenRT,
  title={Baclofen reverses the reduction in prepulse inhibition of the acoustic startle response induced by dizocilpine, but not by apomorphine},
  author={M. Bortolato and R. Frau and Gian Nicola Aru and M. Orru' and G. Gessa},
  journal={Psychopharmacology},
  year={2004},
  volume={171},
  pages={322-330}
}
  • M. Bortolato, R. Frau, +2 authors G. Gessa
  • Published 2004
  • Medicine, Psychology
  • Psychopharmacology
  • RationaleSince baclofen, the prototypical GABAB receptor agonist, is known to reduce the activity of dopaminergic mesolimbic neurons, a putative antipsychotic property of this compound has been suggested, but the evidence for this is still controversial.ObjectivesThe aim of the present study was to elucidate the effects of baclofen on the prepulse inhibition (PPI) of the acoustic startle response (ASR), a behavioral paradigm considered to be one of the most powerful tools for the evaluation of… CONTINUE READING
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