Baclofen reduces GABAA receptor responses in acutely dissociated neurons of bullfrog dorsal root ganglia.

@article{Xi1997BaclofenRG,
  title={Baclofen reduces GABAA receptor responses in acutely dissociated neurons of bullfrog dorsal root ganglia.},
  author={Z X Xi and Keiko Yamada and Masakatsu Tsurusaki and Takashi Akasu},
  journal={Synapse},
  year={1997},
  volume={26 2},
  pages={165-74}
}
The effect of baclofen on the function of the gamma-aminobutyric acidA (GABAA) receptor was examined in acutely dissociated neurons of bullfrog dorsal root ganaglia (DRG) by using the whole-cell voltage-clamp method. Baclofen (0.1-100 microM) depressed the inward currents produced by GABA (100 microM) and muscimol (100 microM). Baclofen shifted the concentration-response curve for GABA (1 microM-1 mM) downward. Baclofen decreased the maximum response (Vmax) to GABA without changing the apparent… CONTINUE READING