Baclofen interactions with nicotine in rats: effects on memory.

  title={Baclofen interactions with nicotine in rats: effects on memory.},
  author={Edward D. Levin and Elyssa Weber and Laura M Icenogle},
  journal={Pharmacology, biochemistry, and behavior},
  volume={79 2},
Nicotine has been shown in numerous previous studies to significantly improve memory on the radial-arm maze, yet the critical mechanisms underlying this effect are not fully characterized. Nicotine stimulates the release of a number of neurotransmitters important for memory function including (gamma-aminobutyric acid) GABA. The importance of nicotinic-GABA interactions regarding memory is currently unknown. The purpose of the current study was to determine the interactive effects of nicotine… CONTINUE READING