Baclofen induces catatonia in rats

@article{Mehta1987BaclofenIC,
  title={Baclofen induces catatonia in rats},
  author={A. Mehta and M. Ticku},
  journal={Neuropharmacology},
  year={1987},
  volume={26},
  pages={1419-1423}
}
Baclofen (10 and 20 mg/kg, i.p.) induced catatonia in rats within 10 min of its administration and the effect lasted for 3 hr. Muscimol (100 ng i.c.v. or 1 mg/kg, i.p.) as well as GABA (5 micrograms i.c.v.) potentiated the effect without producing any effect per se. Bicuculline, bromocriptine and scopolamine failed to modify the catatonia induced by baclofen, thereby ruling out the involvement of GABAA receptors, dopaminergic and cholinergic mechanisms. However, GABAB receptor antagonists, such… Expand
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