Baclofen as an adjuvant analgesic.

  title={Baclofen as an adjuvant analgesic.},
  author={G H Fromm},
  journal={Journal of pain and symptom management},
  volume={9 8},
  • G H Fromm
  • Published 1994 in Journal of pain and symptom management
Baclofen is a gamma-aminobutyric acid (GABA) agonist approved for the treatment of spasticity and commonly used in the management of many types of neuropathic pain. Controlled studies have demonstrated the efficacy of this drug in trigeminal neuralgia. Although its precise mechanism of analgesic action is unknown, it is likely that a drug-induced increase in inhibitory activity is sufficient to interrupt the cascade of neural events that culminates in aberrant activity of wide dynamic range… CONTINUE READING
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