Baclofen antagonizes nicotine-, cocaine-, and morphine-induced dopamine release in the nucleus accumbens of rat.

@article{Fadda2003BaclofenAN,
  title={Baclofen antagonizes nicotine-, cocaine-, and morphine-induced dopamine release in the nucleus accumbens of rat.},
  author={Paola Fadda and Maria Scherma and Alessandra Fresu and Maria Collu and Walter Fratta},
  journal={Synapse},
  year={2003},
  volume={50 1},
  pages={
          1-6
        }
}
Evidence recently provided has suggested a specific involvement of the GABAergic system in modulating positive reinforcing properties of several drugs of abuse through an action on mesolimbic dopaminergic neurons. The GABA(B) receptor agonist baclofen has been proposed as a potential therapeutic agent for the clinical treatment of several forms of drug addiction. In the present study, using the in vivo microdialysis technique, we investigated the effect of baclofen on nicotine, cocaine, and… CONTINUE READING
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