Baclofen: A Preliminary Report of its Pharmacological Properties and Therapeutic Efficacy in Spasticity

@article{Brogden1974BaclofenAP,
  title={Baclofen: A Preliminary Report of its Pharmacological Properties and Therapeutic Efficacy in Spasticity},
  author={Rex N. Brogden and T. M. Speight and G. S. Avery},
  journal={Drugs},
  year={1974},
  volume={8},
  pages={1-14}
}
Baclofen1, a new antispasticity agent, is chemically related to gamma-aminobutyric acid (GABA), a substance which occurs in the brain. It is thought that GABA produces an inhibitory effect on spinal neurones similar to that of naturally occurring inhibitory transmitters. Whereas diazepam, the currently most widely used drug in the treatment of spasticity, acts mainly on supraspinal pathways, baclofen acts predominantly at a spinal level where it inhibits monosynaptic and polysynaptic… CONTINUE READING