Background synaptic activity modulates the response of a modeled purkinje cell to paired afferent input.

@article{Santamaria2005BackgroundSA,
  title={Background synaptic activity modulates the response of a modeled purkinje cell to paired afferent input.},
  author={Fidel Santamaria and James M. Bower},
  journal={Journal of neurophysiology},
  year={2005},
  volume={93 1},
  pages={
          237-50
        }
}
We studied the possible effects of background excitatory and inhibitory synaptic activity on Purkinje cell responses to paired pulse inputs using a morphologically and physiologically detailed compartmental model. Paired-pulse inputs were provided via synapses associated with the ascending segment of the granule cell axon in the presence of variable amounts of background synaptic input provided by parallel fibers and inhibitory interneurons. The results predict the amplitude and dynamics of the… CONTINUE READING

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