Backdoor pathway for dihydrotestosterone biosynthesis: Implications for normal and abnormal human sex development

@article{Fukami2013BackdoorPF,
  title={Backdoor pathway for dihydrotestosterone biosynthesis: Implications for normal and abnormal human sex development},
  author={Maki Fukami and Keiko Homma and Tomonobu Hasegawa and Tsutomu Ogata},
  journal={Developmental Dynamics},
  year={2013},
  volume={242}
}
We review the current knowledge about the “backdoor” pathway for the biosynthesis of dihydrotestosterone (DHT). While DHT is produced from cholesterol through the conventional “frontdoor” pathway via testosterone, recent studies have provided compelling evidence for the presence of an alternative “backdoor” pathway to DHT without testosterone intermediacy. This backdoor pathway is known to exist in the tammar wallaby pouch young testis and the immature mouse testis, and has been suggested to be… 
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