Backbone amide linker strategy: protocols for the synthesis of C-terminal peptide aldehydes.

Abstract

In the backbone amide linker (BAL) strategy, the peptide is anchored not at the C-terminus but through a backbone amide, which leaves the C-terminal available for various modifications. This is thus a very general strategy for the introduction of C-terminal modifications. The BAL strategy was originally developed using a trisalkoxybenzyl linker, but since… (More)
DOI: 10.1007/978-1-62703-544-6_9

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