• Biology, Medicine, Computer Science
  • Published in
    Algorithms for Molecular…
    2009
  • DOI:10.1186/1748-7188-5-6

Back-translation for discovering distant protein homologies in the presence of frameshift mutations

@inproceedings{Grdea2009BacktranslationFD,
  title={Back-translation for discovering distant protein homologies in the presence of frameshift mutations},
  author={Marta G{\^i}rdea and Laurent No{\'e} and Gregory Kucherov},
  booktitle={Algorithms for Molecular Biology},
  year={2009}
}
BackgroundFrameshift mutations in protein-coding DNA sequences produce a drastic change in the resulting protein sequence, which prevents classic protein alignment methods from revealing the proteins' common origin. Moreover, when a large number of substitutions are additionally involved in the divergence, the homology detection becomes difficult even at the DNA level.ResultsWe developed a novel method to infer distant homology relations of two proteins, that accounts for frameshift and point… CONTINUE READING

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