Back to the future: bacteriophages as promising therapeutic tools

  title={Back to the future: bacteriophages as promising therapeutic tools},
  author={Pilar Domingo-Calap and Philippe T Georgel and Seiamak Bahram},
Bacteriophages (phages), natural predators of bacteria, are becoming increasingly attractive in medical and pharmaceutical applications. After their discovery almost a century ago, they have been particularly instrumental in the comprehension of basic molecular biology and genetics processes. The more recent emergence of multi‐drug‐resistant bacteria requires novel therapeutic strategies, and phages are being (re)considered as promising potential antibacterial tools. Furthermore, phages are… 
Bacteriophages: Protagonists of a Post-Antibiotic Era
Interestingly, phages are not only attractive from a clinical point of view, but other areas, such as agriculture, food control, or industry, are also areas for their potential application and this work proposes phages as a real alternative to current antibiotics.
Phages as Promising Biomedical Tools
The large potential of phages as biomedical tools is increasing, thanks to their easy manipulation, high specificify, and low production cost, but ethical concerns and regulatory protocols should be revised in order to give trust to these applications and increase the general acceptance.
Application of Bacteriophages in Nanotechnology
The application of bacteriophages in nanoscience is reviewed, emphasizing bio-related applications, material science, soft matter research, and physical chemistry.
Bacteriophage lambda: The path from biology to theranostic agent.
  • C. Catalano
  • Biology
    Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology
  • 2018
This discussion illustrates how a fundamental understanding of virus assembly has allowed the rational design and construction of semisynthetic nanoparticles as potential theranostic agents and illustrates the concept of benchtop to bedside translational research.
Applications of bacteriophages against intracellular bacteria
This review presents the current state of knowledge regarding the application of bacteriophages against intracellular bacteria and covers phage deployment against the most common intrACEllular pathogens with special attention to therapeutic and preventive strategies.
Directed Evolution of a Mycobacteriophage
Mycobacteriophage adaptation to its host under different conditions is demonstrated and directed evolution could be used for the development of future phage therapy applications against mycobacteria.
Use of bacteriophage to target bacterial surface structures required for virulence: a systematic search for antibiotic alternatives
Examples of how mutations that confer phage resistance produce attenuation are covered, and how this coincidental relationship can be exploited in the search for the next generation of therapeutic agents for bacterial diseases are covered.
Plant/Bacterial Virus-Based Drug Discovery, Drug Delivery, and Therapeutics
This review summarizes the current applications of plant viruses and phages in drug discovery and as drug delivery systems and includes a discussion of the present status of virus-based materials in clinical research, alongside the observed challenges and opportunities.
Bacteriophage therapy to combat antibiotic resistance: A brief review
A brief but comprehensive review of all aspects of natural phage therapy to counter the antibiotic resistance on a global scale is provided.


Bacteriophages and biotechnology: vaccines, gene therapy and antibacterials.
Bacteriophages as potential new therapeutics to replace or supplement antibiotics.
Exploiting gut bacteriophages for human health.
Phage displayed biomolecules as preventive and therapeutic agents.
Some important applications of phage display to identify disease- and pathogen-specific biomolecules are highlighted, making particular emphasis on development ofphage display-derived preventive and therapeutic vaccines.
Phage display: practicalities and prospects
This review discusses the major uses of phage display including its use for elucidating protein interactions, molecular evolution and for the production of recombinant antibodies.
Bacteriophages as vehicles for gene delivery into mammalian cells: prospects and problems
Pros and cons of bacteriophages as GDVs are described, an insight into numerous barriers that bacteriophile face for entry into and subsequent trafficking inside mammalian cells are provided and strategies used to bypass these barriers are elaborate.
Phage therapy pharmacology phage cocktails.
Development of Anti-Infectives Using Phage Display: Biological Agents against Bacteria, Viruses, and Parasites
This review highlights research that exploits phage display technology as a means of discovering novel therapeutics against infectious diseases, with a focus on antimicrobial peptides and antibodies in clinical or preclinical development.
Bacteriophage for biocontrol of foodborne pathogens: calculations and considerations.
This review will discuss issues on the basis of the available literature as well as providing an outlook on the potential of phages in future applications, regarding both immediate and long-term efficacy, consumer safety, and application methods.