Bacillus subtilis functional genomics: global characterization of the stringent response by proteome and transcriptome analysis.

@article{Eymann2002BacillusSF,
  title={Bacillus subtilis functional genomics: global characterization of the stringent response by proteome and transcriptome analysis.},
  author={Christine Eymann and Georg Homuth and Christian Scharf and Michael Hecker},
  journal={Journal of bacteriology},
  year={2002},
  volume={184 9},
  pages={2500-20}
}
The stringent response in Bacillus subtilis was characterized by using proteome and transcriptome approaches. Comparison of protein synthesis patterns of wild-type and relA mutant cells cultivated under conditions which provoke the stringent response revealed significant differences. According to their altered synthesis patterns in response to DL-norvaline, proteins were assigned to four distinct classes: (i) negative stringent control, i.e., strongly decreased protein synthesis in the wild… CONTINUE READING
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