Bacillus subtilis MutS Modulates RecA-Mediated DNA Strand Exchange Between Divergent DNA Sequences

@inproceedings{Carrasco2019BacillusSM,
  title={Bacillus subtilis MutS Modulates RecA-Mediated DNA Strand Exchange Between Divergent DNA Sequences},
  author={Bego{\~n}a Ballesteros Carrasco and Ester Serrano and Alejandro Mart{\'i}n-Gonz{\'a}lez and Fernando Moreno-Herrero and Juan Carlos Alonso},
  booktitle={Front. Microbiol.},
  year={2019}
}
The efficiency of horizontal gene transfer, which contributes to acquisition and spread of antibiotic resistance and pathogenicity traits, depends on nucleotide sequence and different mismatch-repair (MMR) proteins participate in this process. To study how MutL and MutS MMR proteins regulate recombination across species boundaries, we have studied natural chromosomal transformation with DNA up to ∼23% sequence divergence. We show that Bacillus subtilis natural chromosomal transformation… CONTINUE READING
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