Bacillus subtilis DisA helps to circumvent replicative stress during spore revival.

  title={Bacillus subtilis DisA helps to circumvent replicative stress during spore revival.},
  author={Marina Raguse and Rub{\'e}n Torres and Elena Maria Seco and Carolina G{\'a}ndara and Silvia Ayora and Ralf Moeller and Juan Alonso},
  journal={DNA repair},
The mechanisms that allow to circumvent replicative stress, and to resume DNA synthesis are poorly understood in Bacillus subtilis. To study the role of the diadenylate cyclase DisA and branch migration translocase (BMT) RadA/Sms in restarting a stalled replication fork, we nicked and broke the circular chromosome of an inert mature haploid spore, damaged the bases, and measured survival of reviving spores. During undisturbed ripening, nicks and breaks should be repaired by pathways that do not… CONTINUE READING
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