Bacillus clausii Probiotic Strains: Antimicrobial and Immunomodulatory Activities

@article{Urdaci2004BacillusCP,
  title={Bacillus clausii Probiotic Strains: Antimicrobial and Immunomodulatory Activities},
  author={Maria C. Urdaci and Philippe Bressollier and Irina V. Pinchuk},
  journal={Journal of Clinical Gastroenterology},
  year={2004},
  volume={38},
  pages={S86-S90}
}
The clinical benefits observed with probiotic use are mainly attributed to the antimicrobial substances produced by probiotic strains and to their immunomodulatory effects. Currently, the best-documented probiotic bacteria used in human therapy are lactic acid bacteria. In contrast, studies aiming to characterize the mechanisms responsible for the probiotic beneficial effects of Bacillus are rare. The current work seeks to contribute to such characterization by evaluating the antimicrobial and… 

Secreted Compounds of the Probiotic Bacillus clausii Strain O/C Inhibit the Cytotoxic Effects Induced by Clostridium difficile and Bacillus cereus Toxins

This is the first report showing the capacity of a protease secreted by probiotic bacteria to inhibit the cytotoxic effects of toxinogenic C. difficile and B. cereus strains, and could be responsible for the protective effects observed for this human probiotic in antibiotic-associated diarrhea.

Antibiotic Sensitivity of Bacillus clausii Strains in Commercial Preparation

This work extensively redefined the antibiotic susceptibility profile of these four probiotic strains, and extensive comparison with a wild type strain belonging to the normal intestinal microbiome was carried out.

Current Progress and Future Perspectives on the Use of Bacillus clausii

The physiological, antimicrobial, and immunomodulatory properties of probiotic B. clausii strains are summarized and innovative properties based on biochemical investigations of non-probiotic strains of B.Clausii are highlighted, revealing that B.clausii may have further health benefits in other therapeutic areas.

Bacillus clausii-The Probiotic of Choice in the Treatment of Diarrhoea

Experimental data suggest that both Bacillus clausii (B.Clausii) spores and cells can adhere to the bowel wall and colonize the mucosa, and the entire dose of ingested bacteria reach the small intestine intact.

Antimicrobial activity of a meat-borne Bacillussubtilis strain against food pathogens

Results suggest that the antimicrobial compound(s) produced by TR50 could be of proteinaceous nature and require a lipid moiety for activity against the pathogens tested.

Evaluation of Bacillus species as probiotics.

Behavior of Bacillus species in gastrointestinal tract, their mechanisms of action as probiotics, and their possibilities of usage were reviewed.

Composite genome sequence of Bacillus clausii, a probiotic commercially available as Enterogermina®, and insights into its probiotic properties

Various antibiotic resistance, bacteriocins, stress-related, and adhesion-related domains, and industrially-relevant pathways, are identified in the genomes of these probiotic bacteria that are likely to help them survive in the harsh gastrointestinal tract, facilitating adhesion to host epithelial cells, persistence during antibiotic treatment and combating bacterial infections.

Bacillus-derived probiotics: metabolites and mechanisms involved in bacteria-host interactions.

It is concluded that the oxygen-capturing capability and the production of antimicrobials, exoenzymes, competence and sporulation factors (CSF), exopolysaccharides, lactic acid, and cell components are specifically associated with the functional mechanisms of probiotic Bacillus.

Comparative secretome analysis of four isogenic Bacillus clausii probiotic strains

Differences in the secretome of the OC, SIN, NR and T B. clausii strains indicate that specific secretome features characterize each of the four strains despite their genotypic similarity, and indicate that they can cooperate as probiotics as thesecretome components of each strain could contribute to the overall activity of a mixed probiotic preparation.
...

References

SHOWING 1-10 OF 33 REFERENCES

The role of probiotic cultures in the control of gastrointestinal health.

  • R. Rolfe
  • Medicine, Biology
    The Journal of nutrition
  • 2000
Probiotics represent an exciting prophylactic and therapeutic advance, although additional investigations must be undertaken before their role in intestinal health can be delineated clearly.

Probiotics: "living drugs".

  • G. Elmer
  • Biology, Medicine
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists
  • 2001
Effective use of probiotics could decrease patients' exposure to antimicrobials, and live microorganisms or microbial mixtures administered to improve the patient's microbial balance, particularly the environment of the gastrointestinal tract and the vagina.

In Vitro Anti-Helicobacter pyloriActivity of the Probiotic Strain Bacillus subtilis 3 Is Due to Secretion of Antibiotics

ABSTRACT A limited number of antibiotics can be used againstHelicobacter pylori infection, and resistance jeopardizes the success of treatment. Therefore, a search for new agents is warranted. The

The human Lactobacillus acidophilus strain LA1 secretes a nonbacteriocin antibacterial substance(s) active in vitro and in vivo

The spent culture supernatant of strain LA1 (LA1-SCS) contained antibacterial components active against S. typhimurium infecting the cultured human intestinal Caco-2 cells, and the LA1- SCS antibacterial activity was insensitive to proteases and independent of lactic acid production.

Antagonistic activity exerted in vitro and in vivo by Lactobacillus casei (strain GG) against Salmonella typhimurium C5 infection

Comparing the antagonistic properties of Lactobacillus casei GG exerted in vitro against Salmonella typhimurium C5 in a cellular model, cultured enterocyte-like Caco-2 cells, to those exerted in vivo in an animal model, C3H/He/Oujco mice shows that after a single challenge with C5, this strain survives and persists at a higher level in the feces of the untreated conventional mice than in those of the treated group.

In vitro inhibition of Helicobacter pylori NCTC 11637 by organic acids and lactic acid bacteria.

In this study the effects of both pH and organic acids on Helicobacter pylori NCTC 11637 were tested and lactic, acetic and hydrochloric acids demonstrated inhibition of H. pylOR in a concentration-dependent manner with the lactic acid demonstrating the greatest inhibition.

Use of Probiotics in the Treatment of Inflammatory Bowel Disease

Large controlled trials are needed to definitively establish the place for probiotics in the treatment of IBD and resolve issues such as the dose, duration, frequency of treatment, and use of single or multiple strains.

The effect of probiotics on Clostridium difficile diarrhea.

  • M. Pochapin
  • Medicine, Biology
    The American journal of gastroenterology
  • 2000

Sporeformers as Human Probiotics: Bacillus, Sporolactobacillus, and Brevibacillus.

The characterization, efficacy, and safety of sporeformers used as probiotics are reviewed.

Immune protection mediated by the probiotic Lactobacillus rhamnosus HN001 (DR20) against Escherichia coli O157:H7 infection in mice.

  • Q. ShuH. Gill
  • Biology
    FEMS immunology and medical microbiology
  • 2002
Results demonstrate that feeding the probiotic L. rhamnosus HN001 to mice can reduce the severity of E. coli O157:H7 infection, and suggest that this reduction may be associated with enhanced humoral and cellular immune responses.