Bacillus cereus, an unusual cause of fulminant liver failure: diagnosis may prevent liver transplantation.

  title={Bacillus cereus, an unusual cause of fulminant liver failure: diagnosis may prevent liver transplantation.},
  author={Mohamed Saleh and Malik Al Nakib and Alexandra Doloy and S{\'e}bastien Jacqmin and S{\'e}bastien Ghiglione and Nicolas Verroust and Claire Poyart and Yves Ozier},
  journal={Journal of medical microbiology},
  volume={61 Pt 5},
Bacillus cereus is a well-known cause of foodborne disease usually of benign course. Here, we present the case of a 15-year-old boy who developed reversible fulminant liver failure associated with rhabdomyolysis after pasta consumption. Suspecting B. cereus as the aetiological agent may prevent unnecessary liver transplantation. 

Fulminant Bacillus cereus food poisoning with fatal multi-organ failure

This case is the first to use whole genome sequencing techniques to confirm the toxigenic potential of B. cereus, and has important implications for food preparation and storage, particularly given its occurrence in home isolation during the COVID-19 pandemic.

Lifesaving liver transplantation for multi‐organ failure caused by Bacillus cereus food poisoning

The first case of life‐threatening liver failure and severe rhabdomyolysis in this context that could not be survived without emergency hepatectomy and consecutive liver transplantation is reported.

Acute Liver Failure after Ingestion of Fried Rice Balls: A Case Series of Bacillus cereus Food Poisonings

This report exemplifies the necessity of a multidisciplinary approach in cases of Bacillus cereus associated food poisonings to rapidly establish the diagnosis, to closely monitor critically ill patients, and to provide supportive measures for acute liver failure and—whenever necessary—urgent liver transplantation.

The Food Poisoning Toxins of Bacillus cereus

The main focus of this review are the two tripartite enterotoxin complexes Hbl and Nhe, but the latest findings on cereulide and CytK are also presented, as well as methods for toxin detection, and the contribution of further putative virulence factors to the diarrheal disease.

The Bacillus cereus Food Infection as Multifactorial Process

This review aims for risk-oriented diagnostics for enteropathogenic B. cereus infections emerging from food infections withEnteropathogenic strains, also known as toxico-infections, which are the subject of this review.

Multiparametric Quantitation of the Bacillus cereus Toxins Cereulide and Isocereulides A-G in Foods.

A rapid, sensitive, and robust stable isotope dilution assay (SIDA) was developed for the combined quantitation of 1-8 by means of UPLC-MS/MS, and could add an important contribution to the knowledge-based risk assessment of B. cereus toxins in foods.

Distribution of the Emetic Toxin Cereulide in Cow Milk

A clear affinity of cereulide towards the hydrophobic, lipid phase is demonstrated, aligning with Cereulide’s naturally strong hydrophobia properties, suggesting an intensified cereulides analysis of lipid enriched dairy products to prevent severe cereulid intoxications or cross-contamination in processed foods.



Food poisoning as a cause of acute liver failure.

We report a 9-year-old girl with cereulide-producing Bacillus cereus food poisoning, who developed fulminant hepatitis, renal and pancreatic insufficiency, shock, and prolonged seizures. She was

Fatal Family Outbreak of Bacillus cereus-Associated Food Poisoning

A fatal case due to liver failure after the consumption of pasta salad is described and demonstrates the possible severity of the emetic syndrome.

Acute encephalopathy of Bacillus cereus mimicking Reye syndrome

Pathological effect of synthetic cereulide, an emetic toxin of Bacillus cereus, is reversible in mice.

General recovery from the pathological changes and regeneration of hepatocytes was observed after 4 weeks, and the serum values of hepatic enzymes were highest on days 2-3 after the inoculation of cereulide, and rapidly decreased thereafter.

Bacillus cereus, the causative agent of an emetic type of food-borne illness.

This work will summarize the data available for the emetic type of the disease, discuss some new insights in emetic strain characteristics, diagnosis, and toxin synthesis, and summarizes the data involved in the diarrhoeal syndrome and its corresponding toxin.

Toxin gene profiling of enterotoxic and emetic Bacillus cereus.

A molecular assay that targets all toxins known to be involved in food poisoning in a single reaction, using only four different sets of primers was successfully applied to characterize strains from food and clinical diagnostic labs as well as for the toxin gene profiling of B. cereus isolated from silo tank populations.

Emetic toxin formation of Bacillus cereus is restricted to a single evolutionary lineage of closely related strains.

The data provide evidence for a clonal population structure of cereulide-producing emetic B. cereus and indicate that emetic strains represent a highly clonal complex within a potentially panmictic or weakly clonal background populationructure of the species.

Fulminant liver failure in association with the emetic toxin of Bacillus cereus.

Fulminant liver failure developed after the ingestion of food contaminated with the B. cereus emetic toxin, indicating that it caused liver failure in this patient.

Metabolic insights into the hepatoprotective role of N‐acetylcysteine in mouse liver

NAC has a limited capacity to elevate GSH synthesis; increases HTau formation linearly; and improves mitochondrial tricarboxylic acid (TCA) cycle metabolism by stimulation of carbon flux through PDH.