Bacillus anthracis Lethal Toxin Disrupts TCR Signaling in CD1d-Restricted NKT Cells Leading to Functional Anergy

@inproceedings{Joshi2009BacillusAL,
  title={Bacillus anthracis Lethal Toxin Disrupts TCR Signaling in CD1d-Restricted NKT Cells Leading to Functional Anergy},
  author={Sunil Kumar Joshi and Gillian A. Lang and Jason L. Larabee and T. Scott Devera and Lindsay M. Aye and Hemangi B. Shah and Jimmy Dale Ballard and Mark L Lang},
  booktitle={PLoS pathogens},
  year={2009}
}
Exogenous CD1d-binding glycolipid (alpha-Galactosylceramide, alpha-GC) stimulates TCR signaling and activation of type-1 natural killer-like T (NKT) cells. Activated NKT cells play a central role in the regulation of adaptive and protective immune responses against pathogens and tumors. In the present study, we tested the effect of Bacillus anthracis lethal toxin (LT) on NKT cells both in vivo and in vitro. LT is a binary toxin known to suppress host immune responses during anthrax disease and… CONTINUE READING

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