Bacillus anthracis Edema Factor Substrate Specificity: Evidence for New Modes of Action

@inproceedings{Gttle2012BacillusAE,
  title={Bacillus anthracis Edema Factor Substrate Specificity: Evidence for New Modes of Action},
  author={Martin G{\"o}ttle and Stefan Dove and Roland Seifert},
  booktitle={Toxins},
  year={2012}
}
Since the isolation of Bacillus anthracis exotoxins in the 1960s, the detrimental activity of edema factor (EF) was considered as adenylyl cyclase activity only. Yet the catalytic site of EF was recently shown to accomplish cyclization of cytidine 5'-triphosphate, uridine 5'-triphosphate and inosine 5'-triphosphate, in addition to adenosine 5'-triphosphate. This review discusses the broad EF substrate specificity and possible implications of intracellular accumulation of cyclic cytidine 3':5… CONTINUE READING
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