Bach1 is critical for the transformation of mouse embryonic fibroblasts by RasV12 and maintains ERK signaling

@article{Nakanome2013Bach1IC,
  title={Bach1 is critical for the transformation of mouse embryonic fibroblasts by RasV12 and maintains ERK signaling},
  author={Ayako Nakanome and Andrey Brydun and Misako Matsumoto and Kazushige Ota and Ryo Funayama and Keiko Nakayama and Masao Ono and Kiyoto Shiga and Toshiyuki Kobayashi and Kazuei Igarashi},
  journal={Oncogene},
  year={2013},
  volume={32},
  pages={3231-3245}
}
Reactive oxygen species (ROS), by-products of aerobic respiration, promote genetic instability and contribute to the malignant transformation of cells. Among the genes related to ROS metabolism, Bach1 is a repressor of the oxidative stress response, and a negative regulator of ROS-induced cellular senescence directed by p53 in higher eukaryotes. While ROS are intimately involved in carcinogenesis, it is not clear whether Bach1 is involved in this process. We found that senescent Bach1-deficient… CONTINUE READING