Bach1 Represses Wnt/β-Catenin Signaling and Angiogenesis.

  • Li Jiang, Meng Yin, +18 authors Dan Meng
  • Published 2015 in Circulation research

Abstract

RATIONALE Wnt/β-catenin signaling has an important role in the angiogenic activity of endothelial cells (ECs). Bach1 is a transcription factor and is expressed in ECs, but whether Bach1 regulates angiogenesis is unknown. OBJECTIVE This study evaluated the role of Bach1 in angiogenesis and Wnt/β-catenin signaling. METHODS AND RESULTS Hind-limb ischemia… (More)
DOI: 10.1161/CIRCRESAHA.115.306829