Babesia bovis: common protein fractions recognized by oligoclonal B. bovis-specific CD4+ T cell lines from genetically diverse cattle.

@article{Stich1999BabesiaBC,
  title={Babesia bovis: common protein fractions recognized by oligoclonal B. bovis-specific CD4+ T cell lines from genetically diverse cattle.},
  author={Roger William Stich and Allison C. Rice-Ficht and W. M. H. Tuo and Wendy C. Brown},
  journal={Experimental parasitology},
  year={1999},
  volume={91 1},
  pages={40-51}
}
CD4+ helper T cells are believed to be important for inducing protective immunity against Babesia bovis through the production of cytokines, including IFN-gamma, that will provide help to B lymphocytes for IgG production and activate macrophages to become parasiticidal. To provide maximum protection in an outbred population, an effective vaccine against B. bovis should contain antigens that would elicit an IFN-gamma response and would be recognized by cattle with diverse genetic backgrounds. To… CONTINUE READING