BYKdb: the Bacterial protein tYrosine Kinase database


Bacterial tyrosine-kinases share no resemblance with their eukaryotic counterparts and they have been unified in a new protein family named BY-kinases. These enzymes have been shown to control several biological functions in the bacterial cells. In recent years biochemical studies, sequence analyses and structure resolutions allowed the deciphering of a common signature. However, BY-kinase sequence annotations in primary databases remain incomplete. This prompted us to develop a specialized database of computer-annotated BY-kinase sequences: the Bacterial protein tyrosine-kinase database (BYKdb). BY-kinase sequences are first identified, thanks to a workflow developed in a previous work. A second workflow annotates the UniProtKB entries in order to provide the BYKdb entries. The database can be accessed through a web interface that allows static and dynamic queries and offers integrated sequence analysis tools. BYKdb can be found at

DOI: 10.1093/nar/gkr915

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@inproceedings{Jadeau2012BYKdbTB, title={BYKdb: the Bacterial protein tYrosine Kinase database}, author={Fanny Jadeau and Christophe Grangeasse and Lei Shi and Ivan Mijakovic and Gilbert Del{\'e}age and Christophe Combet}, booktitle={Nucleic Acids Research}, year={2012} }