BW1003C87, phenytoin and carbamazepine elevate seizure threshold in the rat amygdala-kindling model of epilepsy.

@article{Morimoto1997BW1003C87PA,
  title={BW1003C87, phenytoin and carbamazepine elevate seizure threshold in the rat amygdala-kindling model of epilepsy.},
  author={Ken Morimoto and Hiroyuki Sato and Keiko Sato and Sadao Sato and Naoko Fukutsuka Yamada},
  journal={European journal of pharmacology},
  year={1997},
  volume={339 1},
  pages={11-5}
}
We examined the anticonvulsant effects of BW1003C87 (5-(2,3,5-trichlorophenyl)-2,4-diaminopyrimidine ethane sulphonic acid), which is structurally related to the new antiepileptic drug, lamotrigine, and compared its effects to those of the conventional antiepileptic drugs, phenytoin and carbamazopine, using the rat amygdala-kindling model of epilepsy. BW1003C87 (2.5-10 mg/kg, i.p.) had potent and long-lasting (48 h after single administration) effects on amygdala-kindled seizures. The effects… CONTINUE READING

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