BW 723C86, a 5-HT2B Receptor Agonist, Causes Hyperphagia and Reduced Grooming in Rats

  title={BW 723C86, a 5-HT2B Receptor Agonist, Causes Hyperphagia and Reduced Grooming in Rats},
  author={Guy A. Kennett and K. Ainsworth and Brenda K Trail and Thomas P Blackburn},

Effects of the 5-HT2C/2B Antagonist SB 206553 on Hyperactivity Induced by Cocaine

Similarities in the action of Ro 60-0175, a 5-HT2C receptor agonist, and d-fenfluramine on feeding patterns in the rat

The hypothesis that activation of 5-HT2C receptors is a critical aspect of the hypophagic action of d-fenfluramine is supported and may prove to be a useful target in the development of clinically effective drugs for the treatment of obesity.

m-CPP-induced self-grooming is mediated by 5-HT2C receptors

Agonist diversity in 5-HT2C receptor-mediated weight control in rats

Together, the difference between compounds in their hypophagic effects and the similarity in their hyperthermic effects suggest a diversity in agonists in 5-HT2C receptor-mediated weight control in rats.



Effects of the 5‐HT2B receptor agonist, BW 723C86, on three rat models of anxiety

In conclusion, BW 723C86 exerted an appreciable anxiolytic‐like profile in a rat social interaction test, but had a weaker effect in the Geller‐Siefter and was ineffective in the elevated x‐maze test used.

m-Chlorophenylpiperazine (mCPP) is an antagonist at the cloned human 5-HT2B receptor.

This study suggests that any 5-HT2B receptor-mediated effects are more likely to result from receptor blockade than from receptor activation, and supports the proposal that at least some of the clinical effects of mCPP are likely to be mediated via stimulation of the 5- HT2C receptor.

In vivo properties of SB 200646A, a 5‐HT2C/2B receptor antagonist

The results indicate that SB 200646A has in vivo efficacy and that 5‐HT2C or 5‐ HT2B receptors are indeed likely to mediate mCPP‐induced hypolocomotion, hypophagia and anxiogenesis and suggest that5‐HT 2C/2B receptor blockade induces anxiolysis.

Further characterization of 5‐hydroxytryptamine receptors (putative 5‐HT2B) in rat stomach fundus longitudinal muscle

It is concluded that despite small differences concerning the enantiomeric selectivity and affinity of rauwolscine and yohimbine, the close pharmacological identity of 5‐HT receptors in rat stomach fundus and the recently cloned 5‐ HT2B receptor is maintained.

Novel discriminatory ligands for 5-HT2B receptors

  • G. Baxter
  • Biology, Chemistry
    Behavioural Brain Research
  • 1995

Characterization and distribution of putative 5‐ht7 receptors in guinea‐pig brain

The distribution of 5‐ht7 receptors in thalamocortical and limbic brain regions suggests a role for these receptors in sensory and affective behaviours in guinea‐pig brain.

In vitro and in vivo profile of SB 206553, a potent 5‐HT2C/5‐HT2B receptor antagonist with anxiolytic‐like properties

The results suggest that SB 206553 is a potent mixed 5‐HT2C/5-HT2B receptor antagonist with selectivity over the 5‐ HT2A and all other sites studied and possesses anxiolytic‐like properties.