BVDV: a pestivirus inducing tolerance of the innate immune response.

@article{Peterhans2013BVDVAP,
  title={BVDV: a pestivirus inducing tolerance of the innate immune response.},
  author={Ernst Peterhans and Matthias Schweizer},
  journal={Biologicals : journal of the International Association of Biological Standardization},
  year={2013},
  volume={41 1},
  pages={
          39-51
        }
}
Animals persistently infected (PI) with bovine viral diarrhea virus (BVDV) retain a strain-specific B- and T-cell immunotolerance. Pestiviral RNA triggers interferon (IFN) synthesis, and the viral RNase E(rns) inhibits IFN expression induced by extracellular viral RNA. In addition, N(pro) promotes the degradation of the transcription factor IRF-3, which effectively blocks IFN expression in BVDV-infected cells. As not all the potential target cells are infected in PI animals, these are 'chimeric… CONTINUE READING
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