BUB1 and BUBR1: multifaceted kinases of the cell cycle

Abstract

The multidomain protein kinases BUB1 and BUBR1 (Mad3 in yeast, worms and plants) are central components of the mitotic checkpoint for spindle assembly (SAC). This evolutionarily conserved and essential self-monitoring system of the eukaryotic cell cycle ensures the high fidelity of chromosome segregation by delaying the onset of anaphase until all chromosomes are properly bi-oriented on the mitotic spindle. Despite their amino acid sequence conservation and similar domain organization, BUB1 and BUBR1 perform different functions in the SAC. Recent structural information provides crucial molecular insights into the regulation and recognition of BUB1 and BUBR1, and a solid foundation to dissect the roles of these proteins in the control of chromosome segregation in normal and oncogenic cells.

DOI: 10.1016/j.tibs.2010.08.004

7 Figures and Tables

020402011201220132014201520162017
Citations per Year

119 Citations

Semantic Scholar estimates that this publication has 119 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@inproceedings{BolanosGarcia2011BUB1AB, title={BUB1 and BUBR1: multifaceted kinases of the cell cycle}, author={Victor M. Bolanos-Garcia and Tom L. Blundell}, booktitle={Trends in biochemical sciences}, year={2011} }