BU48: a novel buprenorphine analog that exhibits delta-opioid-mediated convulsions but not delta-opioid-mediated antinociception in mice.

@article{Broom2000BU48AN,
  title={BU48: a novel buprenorphine analog that exhibits delta-opioid-mediated convulsions but not delta-opioid-mediated antinociception in mice.},
  author={Daniel C. Broom and Luping Guo and Andy Coop and Stephen Husbands and John Watkin Lewis and J. H. Woods and John R. Traynor},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2000},
  volume={294 3},
  pages={1195-200}
}
N-Cyclopropylmethyl-[7alpha,8alpha,2', 3']-cyclohexano-1'[S]-hydroxy-6,14-endo-ethenotetrahydronororip avine (BU48) is a novel, ring-constrained analog of buprenorphine. In vivo, BU48 (0.1-10 mg/kg s.c.) produced brief, nonlethal convulsions in mice followed by brief Straub tail and a short period of catalepsy characteristic of BW373U86 and other nonpeptidic delta-receptor agonists. BU48-induced convulsions were sensitive to antagonism by naltrindole (10 mg/kg s.c.) and were also prevented by… CONTINUE READING
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