BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1

  title={BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1},
  author={N. Watanabe and Maya Gavrieli and J. Sedy and J. Yang and F. Fallarino and S. Loftin and M. Hurchla and N. Zimmerman and J. Sim and X. Zang and T. Murphy and J. H. Russell and J. Allison and K. Murphy},
  journal={Nature Immunology},
  • N. Watanabe, Maya Gavrieli, +11 authors K. Murphy
  • Published 2003
  • Chemistry, Medicine
  • Nature Immunology
  • During activation, T cells express receptors for receiving positive and negative costimulatory signals. Here we identify the B and T lymphocyte attenuator (BTLA), an immunoglobulin domain–containing glycoprotein with two immunoreceptor tyrosine-based inhibitory motifs. BTLA is not expressed by naive T cells, but it is induced during activation and remains expressed on T helper type 1 (TH1) but not TH2 cells. Crosslinking BTLA with antigen receptors induces its tyrosine phosphorylation and… CONTINUE READING
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