BTK Signaling in B Cell Differentiation and Autoimmunity.

@article{Corneth2015BTKSI,
  title={BTK Signaling in B Cell Differentiation and Autoimmunity.},
  author={Odilia B. J. Corneth and Roel G. J. Klein Wolterink and Rudi W Hendriks},
  journal={Current topics in microbiology and immunology},
  year={2015},
  volume={393},
  pages={
          67-105
        }
}
Since the original identification of Bruton's tyrosine kinase (BTK) as the gene defective in the primary immunodeficiency X-linked agammaglobulinemia (XLA) in 1993, our knowledge on the physiological function of BTK has expanded impressively. In this review, we focus on the role of BTK during B cell differentiation in vivo, both in the regulation of expansion and in the developmental progression of pre-B cells in the bone marrow and as a crucial signal transducer of signals downstream of the… CONTINUE READING
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