BST-2 mediated restriction of simian-human immunodeficiency virus.

  title={BST-2 mediated restriction of simian-human immunodeficiency virus.},
  author={Autumn Ruiz and David T. W. Lau and R. S. Mitchell and Maggie S Hill and Kimberly Schmitt and John Guatelli and Edward B. Stephens},
  volume={406 2},
Pathogenic simian-human immunodeficiency viruses (SHIV) contain HIV-1 Vpu and SIV Nef, both shown to counteract BST-2 (HM1.24; CD317; tetherin) inhibition of virus release in a species-specific manner. We show that human and pig-tailed BST-2 (ptBST-2) restrict SHIV. We found that sequential "humanization" of the transmembrane domain (TMD) of the pig-tailed BST-2 (ptBST-2) protein resulted in a fluctuation in sensitivity to HIV-1 Vpu. Our results also show that the length of the TMD in human and… CONTINUE READING


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