BST-2 is a potential activator of invasion and migration in tamoxifen-resistant breast cancer cells.

@article{Yi2013BST2IA,
  title={BST-2 is a potential activator of invasion and migration in tamoxifen-resistant breast cancer cells.},
  author={Eun Hee Yi and Hyouna Yoo and Kum Hee Noh and Songhee Han and Haeri Lee and Jin-Ku Lee and Cheolhee Won and Byung-Hak Kim and Myoung-Hwan Kim and Chung-Hyun Cho and Sang-Kyu Ye},
  journal={Biochemical and biophysical research communications},
  year={2013},
  volume={435 4},
  pages={685-90}
}
Bone marrow stromal cell antigen 2 (BST-2) is a type II transmembrane protein that is known to be a therapeutic target in several types of cancer. However, despite its clinical importance, the roles of BST-2 expression have remained elusive. Here, we found that BST-2 expression is up-regulated in tamoxifen-resistant MCF-7 human breast cancer (TRM-7) cells, resulting in enhanced invasiveness and migration. Matrigel and wound healing assays also showed that overexpression of BST-2 increased… CONTINUE READING

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