BSEP and MDR3 haplotype structure in healthy Caucasians, primary biliary cirrhosis and primary sclerosing cholangitis.

@article{PauliMagnus2004BSEPAM,
  title={BSEP and MDR3 haplotype structure in healthy Caucasians, primary biliary cirrhosis and primary sclerosing cholangitis.},
  author={Christiane Pauli-Magnus and Reinhold Kerb and Karin Fattinger and Thomas Bob Lang and Birgit Anwald and Gerd A Kullak-Ublick and Ulrich H. W. Beuers and Peter Meier},
  journal={Hepatology},
  year={2004},
  volume={39 3},
  pages={779-91}
}
Primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC) are characterized by a cholestatic pattern of liver damage, also observed in hereditary or acquired dysfunction of the canalicular membrane transporters bile salt export pump (BSEP, ABCB11) and multidrug resistance protein type 3 (MDR3, ABCB4). Controversy exists whether a genetically determined dysfunction of BSEP and MDR3 plays a pathogenic role in PBC and PSC. Therefore, 149 healthy Caucasian control individuals… CONTINUE READING

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