BSE infectivity in the absence of detectable PrP(Sc) accumulation in the tongue and nasal mucosa of terminally diseased cattle.

@article{BalkemaBuschmann2011BSEII,
  title={BSE infectivity in the absence of detectable PrP(Sc) accumulation in the tongue and nasal mucosa of terminally diseased cattle.},
  author={Anne Balkema-Buschmann and Martin Eiden and Christine Hoffmann and Martin Kaatz and Ute Ziegler and Markus Keller and Martin H Groschup},
  journal={The Journal of general virology},
  year={2011},
  volume={92 Pt 2},
  pages={467-76}
}
The pathogenesis of bovine spongiform encephalopathy (BSE) infections in cattle has been studied in recent years by using highly sensitive transgenic-mouse bioassays. It has been shown that in this species, the BSE agent amplifies almost exclusively in the central and peripheral nervous system. Even in animals that were killed in the clinical end stage of the disease, the lymphoreticular system was shown to be free of the infectious agent. No other animal species investigated to date exhibits… CONTINUE READING

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