BRSK2 is activated by cyclic AMP-dependent protein kinase A through phosphorylation at Thr260.

@article{Guo2006BRSK2IA,
  title={BRSK2 is activated by cyclic AMP-dependent protein kinase A through phosphorylation at Thr260.},
  author={Zekun Guo and Wenwen Tang and Jian Yuan and Xinya Chen and Bangqian Wan and Xiuting Gu and Kuntian Luo and Yingli Wang and Long Yu},
  journal={Biochemical and biophysical research communications},
  year={2006},
  volume={347 4},
  pages={
          867-71
        }
}
Brain selective kinase 2 (BRSK2) has been identified as a member of AMPK related kinases. LKB1 can phosphorylate the Thr174 of BRSK2, increasing its activity >50-fold. In this study, we identified cAMP-dependent protein kinase A (PKA) as another upstream kinase of BRSK2, which can phosphorylate BRSK2 at Thr260. The association between these two proteins was confirmed by GST pull-down. Furthermore, our study indicated that the kinase activity of BRSK2 can be increased through phosphorylation by… CONTINUE READING
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