• Corpus ID: 31725692

BRL 17421 , a Novel f ,-Lactam Antibiotic , Highly Resistant to , 8-Lactamases , Giving High and Prolonged Serum Levels in Humans

@inproceedings{SlocombeBRL1,
  title={BRL 17421 , a Novel f ,-Lactam Antibiotic , Highly Resistant to , 8-Lactamases , Giving High and Prolonged Serum Levels in Humans},
  author={Brian Slocombe and Michael J. Basker and Peter H. Bentley and John Peter Clayton and Martin Cole and K. R. Comber and Ronald A. Dixon and R. A. Edmondson and D. Jackson and David J. Merrikin and Robert Sutherland}
}
BRL 17421 is a new semisynthetic /3-lactam antibiotic with an unusual spectrum of antibacterial activity. The compound exhibits exceptional stability to a wide range of bacterial /8-lactamases and is active against the majority of Enterobacteriaceae, including strains highly resistant to many of the penicillins and cephalosporins currently available. Among the clinical isolates of Enterobacteriaceae tested, the frequency of strains resistant to BRL 17421 was found to be low, and there was a… 

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  • Biology, Medicine
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  • 1982
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  • Medicine, Biology
    Antimicrobial Agents and Chemotherapy
  • 1982
TLDR
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Resurrecting Old β-Lactams: Potent Inhibitory Activity of Temocillin against Multidrug-Resistant Burkholderia Species Isolates from the United States
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Temocillin is a β-lactam with potent activity against Burkholderia spp.
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