BRL 17421, a novel beta-lactam antibiotic, highly resistant to beta-lactamases, giving high and prolonged serum levels in humans

@article{Slocombe1981BRL1A,
  title={BRL 17421, a novel beta-lactam antibiotic, highly resistant to beta-lactamases, giving high and prolonged serum levels in humans},
  author={Brian Slocombe and Michael J. Basker and Peter H. Bentley and John Peter Clayton and Martin Cole and K. R. Comber and Ronald A. Dixon and R. A. Edmondson and D. Jackson and David J. Merrikin and Robert Sutherland},
  journal={Antimicrobial Agents and Chemotherapy},
  year={1981},
  volume={20},
  pages={38 - 46}
}
BRL 17421 is a new semisynthetic beta-lactam antibiotic with an unusual spectrum of antibacterial activity. The compound exhibits exceptional stability to a wide range of bacterial beta-lactamases and is active against the majority of Enterobacteriaceae, including strains highly resistant to many of the penicillins and cephalosporins currently available. Among the clinical isolates of Enterobacteriaceae tested, the frequency of strains resistant to BRL 17421 was found to be low, and there was a… 
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