BRL 17421, a novel beta-lactam antibiotic, highly resistant to beta-lactamases, giving high and prolonged serum levels in humans

  title={BRL 17421, a novel beta-lactam antibiotic, highly resistant to beta-lactamases, giving high and prolonged serum levels in humans},
  author={Brian Slocombe and Michael J. Basker and Peter H. Bentley and John Peter Clayton and Martin Cole and K. R. Comber and Ronald A. Dixon and R. A. Edmondson and D. Jackson and David J. Merrikin and Robert Sutherland},
  journal={Antimicrobial Agents and Chemotherapy},
  pages={38 - 46}
BRL 17421 is a new semisynthetic beta-lactam antibiotic with an unusual spectrum of antibacterial activity. The compound exhibits exceptional stability to a wide range of bacterial beta-lactamases and is active against the majority of Enterobacteriaceae, including strains highly resistant to many of the penicillins and cephalosporins currently available. Among the clinical isolates of Enterobacteriaceae tested, the frequency of strains resistant to BRL 17421 was found to be low, and there was a… 
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New 7-methoxycephem antibiotics of bacterial origin found in culture filtrates of a bacterium isolated from a plant and named cephabacin M1-6 exhibited moderate antibacterial activity against Gram-negative and Gram-positive bacteria.
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The in vitro activity and β-lactamase stability of 7-[d(−)-α-(4-ethyl-2,3-dioxopiperazino-carbonylamino) -p-hydroxyphenylacetamido]-3-cephem-4-carboxylic acid (cefoperazone) were compared with the activities and stabilities of other cephalosporins and cephamycins.
GR 20263, a new broad-spectrum cephalosporin with anti-pseudomonal activity
GR 20263 is a new broad-spectrum injectable cephalosporin which is stable to most beta-lactamases, and produces high, long-lasting blood levels, with much of the antibiotic being recovered in the urine.
Influence of protein binding of antibiotics on serum pharmacokinetics and extravascular penetration: clinically useful concepts.
The extravascular distribution, tissue binding, and free-drug concentration of an antibiotic can be accurately predicted from serum kinetics and serum protein binding.
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