BRIEF REPORT: Single exposure to cocaine or ecstasy induces DNA damage in brain and other organs of mice

  title={BRIEF REPORT: Single exposure to cocaine or ecstasy induces DNA damage in brain and other organs of mice},
  author={Tathiana Aparecida Alvarenga and Monica Levy Andersen and Daniel Araki Ribeiro and Paula Araujo and Camila Hirotsu and Jos{\'e} Luiz Costa and Murilo Campos Battisti and S{\'e}rgio Tufik},
  journal={Addiction Biology},
We evaluated the overall genetic damage induced by different doses of cocaine and MDMA (3,4‐Methylenedioxymethamphetamine) in several organs. One hour after intraperitoneal drug administration, mice were euthanized; peripheral blood, liver and brain were collected, and the cellular suspensions were used for the single cell gel (comet) assay. We determined that all doses of cocaine and MDMA tested were able to induce DNA damage in blood cells. Extensive genotoxic damage was induced by cocaine or… 
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